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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

///N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid powder is a piperazinyl phenyl urea whose structure is different from alkyl carbamates and alpha-keto heterocyclic compounds and is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH)(IC50s = 34 and 33 nM in rat and human, respectively) that is able to cross the blood-brain barrier.1 At 20 mg/kg, covalently binds to the active site of FAAH through cleavage of the urea functionality generating aniline and a FAAH-poperazinyl carbamate.

Additional information

CAS No.

681136-29-8

Molecular Formula

C19H19N5OS

Molecular Weight

365.459 g*mol-1

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